Demonstrated effectiveness

See how Interceptor® Plus (milbemycin oxime/praziquantel) has demonstrated palatability and effectiveness for heartworm disease prevention in clinical trials.

Success in controlled laboratory studies

The two active ingredients in Interceptor Plus prevents heartworm disease and treats and controls: hookworms, roundworms, whipworms and tapeworm

Heartworm disease prevention

In a controlled laboratory study, Interceptor Plus was 100% effective against induced heartworm infections when administered once monthly for 6 consecutive months.


In a field study of 115 dogs, overall acceptability was 96.6%. 1 dog (0.9%) accepted it from the bowl with food, 2 dogs (1.7%) accepted it when it was placed in their mouth, and 4 dogs (3.5%) refused it.

Product safety information

For complete safety, administration, and dosage information, and possible side effects, download the Interceptor Plus product label.

Resources for you

Take a look at our resource page to find out about an effective heartworm preventive and protection against nasty intestinal worms.

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Interceptor Plus prevents heartworm disease and treats and controls adult roundworm, hookworm, whipworm, and tapeworm infections in dogs and puppies 6 weeks or older and 2 pounds or greater.


Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Interceptor Plus, dogs should be tested for existing heartworm infections. The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females. The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, decreased activity, incoordination, weight loss, convulsions, weakness, and salivation. For complete safety information, please see Interceptor Plus product information or ask your veterinarian.

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