Trifexis® (spinosad + milbemycin oxime) is a monthly, beef-flavored tablet that kills fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm and whipworm infections.
Parasites affect their hosts, such as wildlife, people and pets. A proactive approach to protecting your dog is with Trifexis, the #1 prescribed1 combo parasite protection. Learn more about how Trifexis protects your dog from fleas, heartworm disease and three kinds of intestinal parasites.
Kills fleas on dogs and prevents infestations
Prevents heartworm disease in dogs
Treats and controls hookworm, roundworm and whipworm infections
Protects against fleas, heartworm disease, hookworm, roundworm and whipworm.
Oral beef-flavored tablet that’s easy to administer
Convenient once-a-month dosing
Protect all month long with just one tablet
Approved for puppies and dogs 8 weeks and older, and who weigh 5 pounds or more
Want to keep reading? Find more useful resources about effective parasite protection and treatment for your dog.
See how Trifexis' mode of action provides effective protection against fleas, heartworm disease, and three harmful intestinal parasites.
Trifexis is available in 5 different strengths according to weight and is safe when used according to the label directions for pup through to adult.
Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.
The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.