Dosing & Administration

Learn how to dose Trifexis® (spinosad + milbemycin oxime) correctly to deliver effective treatment and protection against fleas, heartworm disease, hookworm, roundworm and whipworm.

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How to Give Your Dog Trifexis?

Trifexis is a beef-flavored, chewable tablet that you can offer to your dog like a treat. It doesn’t have to be chewed – you can give it to your dog like any other tablet medicine. Give your dog Trifexis with food for maximum effectiveness.

Once your dog has swallowed the tablet, Trifexis gets to work on killing fleas, preventing heartworm disease, and protecting against intestinal parasites. Follow the advice of your veterinarian for the correct dosing for your dog.

Dose According to Your Pet’s Weight

You should administer one tablet once every month to provide year-round protection for dogs and puppies 8 weeks and older and 5 pounds or greater.

Dosing

Dog weight - Spinosad per chewable tablet (mg)
5 - 10 lbs. - 140
10.1 - 20 lbs. - 270
20.1 - 40 lbs. - 560
40.1 - 60 lbs. - 810
60.1 - 120 lbs. - 1620
Greater than 120 lbs. - Administer the appropriate combination of chewable tablets
Dog weight - Milbemycin oxime per chewable tablet (mg)
5 - 10 lbs. - 2.3
10.1 - 20 lbs. - 4.5
20.1 - 40 lbs. - 9.3
40.1 - 60 lbs. - 13.5
60.1 - 120 lbs. - 27
Greater than 120 lbs. - Administer the appropriate combination of chewable tablets
Dog weight - Chewable tablets administered
5 - 10 lbs. - One
10.1 - 20 lbs. - One
20.1 - 40 lbs. - One
40.1 - 60 lbs. - One
60.1 - 120 lbs. - One
Greater than 120 lbs. - Administer the appropriate combination of chewable tablets

Administration Guidelines

Trifexis is a beef-flavored tablet that’s easy to administer to your dog for month-long protection.

Give with Food

Make sure your dog eats along with Trifexis to ensure optimal efficacy.

Administer the Tablet

Give your dog the tablet to take orally either as a treat, or hidden in their food.

Observe Your Dog

Keep an eye on your dog for one hour after administration, and if vomiting occurs, redose.

Product Safety Information

For complete safety information, please see the Trifexis product label or ask your veterinarian.

Get Trifexis

Protect your dog year-round against fleas, heartworm disease, hookworm, roundworm and whipworm with monthly Trifexis, the #1 prescribed combo parasite protection for dogs.1

Questions About Trifexis?

Have questions about Trifexis? Find answers to the most frequently asked questions below.

Indications

Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Important Safety Information

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.


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Protect your dog all month long from fleas, heartworm disease and intestinal parasites with Trifexis.

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