Convenient Treatment & Protection

Trifexis® (spinosad + milbemycin oxime) makes protection easy against fleas, heartworm disease and three types of intestinal parasites with one chewable tablet every month.

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Why Switch to Trifexis

Life can get busy. Responsibilities pile up, your calendar gets full and it just seems that sometimes things get lost in the shuffle. But with Trifexis, you can simplify your dog’s preventative routine. Trifexis is a monthly beef-flavored tablet that keeps your dog protected against fleas, heartworm disease and intestinal parasites all month long.

Competitor Comparison


Trifexis® (spinsoad + milbemycin oxime)Kills fleas and prevents flea infestations
Prevents heartworm disease
Treats and controls adult hookworm
*
Treats and controls adult roundworm
Treats and controls adult Whipworm
Heartgard® Plus (ivermectin/pyrantel)Kills fleas and prevents flea infestations Prevents heartworm disease
Treats and controls adult hookworm
†‡
Treats and controls adult roundworm
Treats and controls adult Whipworm
NexGard® (afoxolaner)Kills fleas and prevents flea infestations
Prevents heartworm disease Treats and controls adult hookworm Treats and controls adult roundworm Treats and controls adult Whipworm
Bravecto® (fluralaner)Kills fleas and prevents flea infestations
Prevents heartworm disease Treats and controls adult hookworm Treats and controls adult roundworm Treats and controls adult Whipworm
Simparica® (sarolaner)Kills fleas and prevents flea infestations
Prevents heartworm disease Treats and controls adult hookworm Treats and controls adult roundworm Treats and controls adult Whipworm

*A. caninum

A. caninum, U. stenocephala, A. braziliense

NexGard, Bravecto and Simparica also kill ticks. These comparisons are based on label information.

Trifexis is a combination of flea medication, heartworm disease prevention and intestinal parasite control. That’s why Trifexis is the #1 prescribed combo parasite protection for dogs.1

Learn How Trifexis Works

Questions About Trifexis?

Find answers to the most frequently asked questions below.

Indications

Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Important Safety Information

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.


Get Trifexis

Protect your dog all month long from fleas, heartworm disease and intestinal parasites with Trifexis.

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